Publications

Publications

Independent Research:

  1. W. Wang†, H. Guo†, X. Yan†, X. Pan, X. Wang, Y. Rong, Z. Bai, L. Zhang, Z. Wu, X. Zhao, W. Huang, W. Qin, and L. Chu* Silicon-rhodamine-enabled Identification (SeeID) for Near-Infrared Light Controlled Proximity Labeling In Vitro and In Vivo. Nature Communications 2025, 16, 8134. [pdf]
  2. L. Tu†, H. Qin†, S. Luo, X. Liu, R. Zhao, X. Ding, S. Zhang, L. Chu* Ligand-induced Self-Complementing tag (LiSC-tag) as an epitope tag for live-cell super-resolution imaging and functional manipulation of cellular proteins. J. Am. Chem. Soc. 2025, 147, 36210-36222. [pdf]
  3. X. Yan, J.-H. Zhao, Q. Wang, W. Wang, Y. Ding, Y. Zhou, G. Chen, J. Du, W. Huang, L. Chu* Silicon Rhodamine-Catalyzed Near-Infrared Light-Induced Photodecaging of Ortho-Nitrobenzyl Groups In Vitro and In Vivo. J. Am. Chem. Soc. 2025, 147, 20957-20966. [pdf]
  4. X. Sun, Y. Zhang, W. Lu, H. Guo, G. He, S. Luo, H. Guo, Z. Zhang, W. Wang, L. Chu, X. Liu, W. Qin Precise and In Vivo-Compatible Spatial Proteomics via Bioluminescence-Triggered Photocatalytic Proximity Labeling. ACS Central Science 2025, 11, 1611-1626. [pdf]
  5. II. Ng, Z. Zhang, K. Xiao, M. Ye, T. Tian, Y. Zhu, Y. He, L. Chu, H. Tang Targeting WEE1 in tumor-associated dendritic cells potentiates antitumor immunity via the cGAS/STING pathway. Cell Reports 2025, 44, 115733. [pdf]
  6. T. Yang, J. He, X. Zhao, C. Ren, Z. Ding, L. Wang, H. Zhao, L. Chu, S. Luo, C. Shi, L. Gu, T. Xu, Ge Yang, W. Ji Self-adaptive fine-tuning of deep learning super-resolution microscopy for artifact suppression in live-cell imaging. The Innovation 2025, online now. [pdf]
  7. Q. Wang, Y. Song, S. Yuan, Y. Zhu, W. Wang and L. Chu* Prodrug activation by 4,4’-bipyridine-mediated aromatic nitro reduction. Nature Communications 2024, 15, 8643. [pdf]
  8. Y. Wang, S. Luo, H. Su, Z. Wang*, L. Chu* and C. Zhang* BL-918 activates PINK1/Parkin signaling pathway to ameliorate the progression of Parkinson’s disease. J. Biol. Chem. 2024, 300, 107543.[pdf]
  9. Y. Zhu†, X. Yan†, Y. Chi, B. Liu, W. Huang and L. Chu* Near-Infrared Light Controlled Protein Degradation by Photo-caged Lenalidomide and Pomalidomide. Bioorganic Chemistry 2024, 143, 107050. [pdf]
  10. Y. Hou , Z. Wang , P. Liu , X. Wei, Z. Zhang, S. Fan, L. Zhang, F. Han, Y. Song, L. Chu, C. Zhang* SMPDL3A is a cGAMP-degrading enzyme induced by LXR-mediated lipid metabolism to restrict cGAS-STING DNA sensing. Immunity 2023, 56, 2492-2507. [pdf]
  11. Z. Du, W. Wang, S. Luo, L. Zhang, S. Yuan, Y. Hei, Z. Bao, C. Chen, Y. Lin, and L. Chu* Self-Renewable Tag for Photostable Fluorescence Imaging of Proteins. J. Am. Chem. Soc. 2023, 145, 18968-18976. [pdf]

Prior to Tsinghua University:

  1. K.T.G. Samarasinghe, E. An, M.A. Genuth, L. Chu, S.A. Holley, C.M. Crews, OligoTRAFTACs: A generalizable method for transcription factor degradation. RSC Chem. Biol. 2022, 3, 1144-1153. [pdf]
  2. J. Tyson,  K. Hu, S. Zheng, P. Kidd, N. Dadina, L. Chu, D. Toomre, J. Bewersdorf, A. Schepartz, Extremely Bright, Near-IR Emitting Spontaneously Blinking Fluorophores Enable Ratiometric Multicolor Nanoscopy in Live Cells. ACS Cent. Sci. 2021, 7, 1419-1426. [pdf]
  3. M. J. Bond†, L. Chu†, D. A. Nalawansha, K. Li, C. Crews Targeted Degradation of Oncogenic KRASG12C by VHL-recruiting PROTACs. ACS Cent. Sci. 2020, 6, 1367-1375. (†equal contributions) [pdf]
  4. L. Chu, J. Tyson, J. Shaw, F. Rivera-Molina, A. Koleske, D. Toomre, and A. Schepartz Two-color nanoscopy of organelles for extended times with HIDE probes. Nat. Comm. 2020, 11, 4271. [pdf]
  5. Z. Jin†, L. Chu†, Y. Chen, and J.-Q. Yu Pd-Catalyzed Remote meta-C–H Functionalization of Phenylacetic Acids Using a Pyridine Template. Org. Lett. 2018, 20, 425-428. (†equal contributions) [pdf]
  6. E. Plata, D. E. Hill, B. E. Haines, D. G. Musaev, L. Chu, D. P. Hickey, M. S. Sigman, J.-Q. Yu and D. G. Blackmond A Role for Pd(IV) in Catalytic Enantioselective C–H Functionalization with Monoprotected Amino Acid Ligands under Mild Conditions. J. Am. Chem. Soc. 2017, 139, 9238-9245. [pdf]
  7. K. J. Xiao, L. Chu, G. Chen, J.-Q. Yu Kinetic resolution of benzylamines via Palladium(II)-catalyzed C–H cross-coupling. J. Am. Chem. Soc.2016, 138, 7796-7780. [pdf]
  8. K. J. Xiao, L. Chu, J.-Q. Yu Enantioselective C–H olefination via kinetic resolution. Angew. Chem. Int. Ed. 2016, 55, 2856-2860. [pdf]
  9. L. Chu, M. Shang, K. Tanaka, Q. Chen, N. Pissarnitski, E. Streckfuss, and J.-Q. Yu Remote meta-C–H activation using a pyridine-based template: achieving site-selectivity via the recognition of distance and geometry. ACS Cent. Sci. 2015, 1, 394-399. [pdf]
  10. D. Zhu, G. Yang, J. He, L. Chu, G. Chen, W. Gong, K. Chen, M. D. Eastgate, J.-Q. Yu Ligand-promoted ortho-C−H amination with Pd catalysts. Angew. Chem., Int. Ed. 2015, 54, 2497-2500. [pdf]
  11. L. Chu, K. -J. Xiao, J.-Q. Yu Room-temperature enantioselective C–H iodination via kinetic resolution. Science2014, 346, 451-455. [pdf]
  12. K. S. L. Chan, M. Wasa, L. Chu, B. N. Laforteza, M. Miura, J.-Q. Yu Ligand-enabled cross-coupling of C(sp3)–H bonds with arylboron reagents via Pd(II)/Pd(0) catalysis. Nature Chem. 2014, 6, 146-150. [pdf]
  13. L. Chu, X. -C. Wang, C. E. Moore, A. L. Rheingold, J.-Q. Yu Pd-catalyzed enantioselective C–H Iodination: asymmetric synthesis of chiral diarylmethylamines. J. Am. Chem. Soc. 2013, 135, 16344-16347. [pdf]
  14. R. Shang, Z. Huang, L. Chu, Y. Fu, L. Liu Palladium-catalyzed decarboxylative coupling of potassium nitrophenyl acetates with aryl halides. Org. Lett. 2011, 13, 4240-4243. [pdf]
  15. R. Shang, D. S. Ji, L. Chu, Y. Fu, L. Liu Synthesis of α-aryl nitriles through palladium-catalyzed decarboxylative coupling of cyanoacetate salts with aryl halides and triflates. Angew. Chem., Int. Ed. 2011, 50, 4470-4474. [pdf]